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Max Holloway is out of UFC 222, and will not defend his UFC featherweight title against Frankie Edgar.

The featherweight champion is believed to have suffered a leg injury in training, and despite his best efforts, is unable to compete in March. What the UFC are going to do as far as UFC 222’s main event goes is as yet uncertain, but for Holloway, he’s mainly focused on returning to action as soon as possible.

“I asked the docs if we could cut off my leg then ask the commission if I could fight handicapped,” Holloway posted to Twitter. “They told me at the end of the day it is what it is… Had dozens of family from Hawaii coming up for this one… I know it sucks but hang in there. We’re going to reschedule ASAP.”

This is the second occasion Edgar vs. Holloway has fallen through. The pair were originally meant to meet at UFC 218 in Detroit last year, only for Edgar to suffer an injury to his orbital bone, leaving Holloway to face late replacement Jose Aldo.

That being said, the 145-pound champ is asking fans not to lose patience with the match up.

“I know it sucks but don’t give up on the sport,” Holloway said to a fan online. “Card changes have always been part of it. Changes are opportunities for other fighters to get their shot. Surprises are what make this sport unique. Hang on and I’ll find you at the next one.”